29 The positive correlation found between the final respiratory rate and the difference between the walked and predicted
distances indicates worse performance at the test. This is consistent with a study of 30 children and adolescents with CKD, where an association was observed between shorter walked distance and an increase in the final respiratory rate, blood pressure, pulse oxygen saturation, and Borg perceived exertion, thus suggesting a worse performance in functional activities.4 Functional capacity assessed by the mean walked distance at the 6MWT found in the present study (396 ± 71.2 meters) was lower than that observed in other studies, whose mean walked distances ranged from 515 to 560 meters. However, in all these studies, the values were significantly Anti-diabetic Compound Library lower than those predicted.4, 18 and 26 Several anthropometric, clinical, and biological factors can influence children with CKD to have poorer performance http://www.selleckchem.com/products/MK-2206.html in physical activities, such as maternal education, body mass index (BMI), height, and age. A study demonstrated that children of mothers with higher educational
level were more active when compared to children of less educated mothers.30 Regarding the correlations between walked distance and variables of interest in the study, it was observed that the older the children and adolescents were, the better their performance at the 6MWT, indicating better functional capacity. Another study also found a positive correlation between age and walked distance, demonstrating that the older the age, PJ34 HCl the better the functional capacity.26 Regarding the correlation between functional capacity assessed by the 6MWT, it can be observed that taller patients walked a significantly greater distance when compared with healthy children. A Belgian study of 25 children with CKD observed that height is an important factor for the distance walked during the 6MWT, explained
by the fact that taller individuals have greater stride length and better performance at the test.18 Regarding gender, male individuals showed better performance at the 6MWT. The present data are consistent with a study conducted in China, which found higher exercise capacity and better performance at the 6MWT in healthy male children, probably as a result of their greater muscle mass.17 Conversely, a U.S. study with 44 participants assessed physical activity in CKD patients aged 7 to 20 years, and observed that females walked a greater distance than males in the 6MWT.26 The positive correlation between distance walked and QoL perceived by the children demonstrated that the greater the distance walked, the better the score; however, the authors did not find other studies related to these findings in the literature.