1, SAS Inc., Cary, NC, USA) except MCA which was conducted with XLStat 2007.5 software (Addinsoft, Paris, France). Between June 2005 and May 2009, travel outside Canada was recorded in 493 cases reported in the study area. Six of these cases reported onset dates before their departure dates, three cases reported onset dates after departure and before the minimum incubation period, and 38 cases reported onset dates after their return

dates and find more beyond the maximum incubation period. Thus, these 47 cases were considered as DC, leaving 446 TRC for analysis. The three most frequent diseases among TRC were Campylobacter enteritis, non-typhoidal salmonellosis, and giardiasis, accounting for three quarters of the cases (Table 1). Thirty-four cases were hospitalized; the most with salmonellosis (12 cases) or paratyphoid or typhoid fever (9 cases) (Table 1). Overall, the Epacadostat most common symptoms were diarrhea (77%), abdominal pain (58%), malaise (52%), fever (51%), nausea (44%), and headache (36%) with some variations between illnesses (Table 1). The onset date was available for 379 cases (85%)

with the following yearly distribution (from June to May the following year): 82 cases in 2005 to 2006, 117 cases in 2006 to 2007, 97 cases in 2007 to 2008, and 83 cases in 2008 to 2009. The total monthly distribution combined over 4 years ranged from 23 cases in October to 51 cases in August. No significant differences were found between years and months. Both onset and return dates were recorded in 353 cases (79%). The onset date for 204 of these cases (58%) occurred after their return date; and within the first 4 days for 75% of them (Figure 1). The other cases (148/353 or 42%) became ill while abroad, within the last 7 days prior to return for 60% of them (Figure 1). Among the cases who became ill abroad with known departure date (n = 143), the delay between

departure and onset dates had the following quartiles: 5 (Q1), 7 (median), and 20 days (Q3). Overall, 50.4% TRC were Histidine ammonia-lyase male with some variations between diseases (Table 2). Age ranged from a few months to 80 years with a right skewed distribution, the quartiles being 12 (Q1), 26 (median), and 46 (Q3). The disease-specific age distribution showed potentially different patterns; cryptosporidiosis TRC were less than 40 years old, cyclosporiasis TRC over 25 years, and hepatitis A TRC under 25 years (Table 2). Among the 446 TRC, 42 (9.4%) were classified as new immigrants as a result of adoption (6 cases), refugee status (16 cases), or immigration (20 cases). Most of them were in the 5 to 14 years (23 cases) or <5-year-age groups (8 cases). Overall, the main destinations were to Latin America/Caribbean (160 cases) and Asia (134 cases), with some variations between the diseases (Table 3). Destination for cases identified as new immigrants were Asia (23 cases), Africa (12 cases), and Latin America/Caribbean (7 cases).