20 Dementia with Lewy bodies (DLB) completely breaks the traditional mold in dementia by having attention deficits identified as a core feature of the syndrome.22 These patients also have larger attentional deficits than AD patients while, like HD and VaD patients, they have relatively preserved episodic memory.21,23

Further, the attentional deficits seen in DLB are not. only quantitatively, but Inhibitors,research,lifescience,medical also qualitatively different from those seen in AD. For example, the variability in reaction times in a 90-s computerized test of attention, choice reaction time, can discriminate between the two types of dementia with a sensitivity of 81% and a specificity of 92%.21 Importantly, different profiles of attentional impairment, can be seen in all the major types of dementia (VaD, AD, and DLB21), probably reflecting the differing etiologies of the conditions. Thus, DLB can also be differentiated from VaD Inhibitors,research,lifescience,medical with a sensitivity of 81% and a specificity of 82%, while AD can be differentiated from VaD with a sensitivity of 64% and a specificity of 77 %.21 Attentional impairments have also been seen in first time diagnosed unmeditated Parkinson’s disease patients,24 Parkinson’s dementia,25 and elderly Inhibitors,research,lifescience,medical stroke patients actually free from dementia.26 Besides marked deficits to

attention,27 demented patients show marked reductions in the speed with which they can recognize previously presented information (words, pictures, faces5,6,23). These deficits are also characteristic of mild cognitive impairment. (MCI)28 and add a further dimension to our knowledge of the cognitive deficit profiles in the dementias that have gone undetected by nonautomated assessments like the ADAS. The behavioral impact of delays in time to retrieve information from working Inhibitors,research,lifescience,medical and secondary memory is manifest in a variety of behavioral situations. For example, in social situations, in which not only is the patient clearly forgetful,

but even when items are retrieved or objects (or people) recognized, the increased time lag makes social Inhibitors,research,lifescience,medical interactions more stressed and unsatisfactory. Other examples are patients not remembering the name of someone until after they have passed by in the street, or remembering to do something too late or in those the wrong context. Historical perspectives on cognitive assessment of dementia Alzheimer’s disease Since the registration of the anticholinesterase, tacrine, for the symptomatic treatment of AD in the late 1980s, the cognitive outcome measure most frequently used in clinical drug trials for new dementia drugs has been the cognitive subscale of the ADAS (ADAS-COG). However, the ADAS-COG Paclitaxel ic50 features some well-recognized deficiencies,29-31 which, as the following examples will illustrate, have been recognized by the International Working Group on Dementia Drug Guidelines7: A generally acknowledged limitation of the ADAS-COG is that it lacks a subset for attention. […