5 and 24.9 reported migraine attacks occurring 10-14 days per month, 13.6% (OR 2.9; CI: 1.9-4.4) of those with a BMI ≥ 30 reported attacks between 10 and 14 days per month.30 In

the second general population study, Keith et al conducted a meta-analysis of data from women in 11 different general population databases (Table 4).31 Demographics, self-report of headache or migraine and TBO was obtained from over 200,000 women, ranging in RXDX-106 order age from 16 to 94 years. TBO was estimated in all but one of the 11 datasets using self-reported height and weight. Although migraine prevalence was not able to be shown to be associated with TBO, obese women had an increase risk for headache as compared with those with a BMI of 20. The above studies were subsequently followed by 2 studies which evaluated the prevalence of migraine or selleck compound severe headaches in those with obesity using measured body mass indices.14,32 In the first of these studies, Ford et al evaluated 7601 participants ranging

in age from 20 to 85 years of age.32 Migraine or severe headaches was self-reported by participants. TBO was estimated using measured height and weight to calculate the BMI. Similar to the study by Bigal, migraine prevalence was increased in those who were underweight. In addition those with TBO had a 37% increased odds for having migraine or severe headaches compared with those of normal weight, (OR 1.37; CI: 1.09-1.72).32 In the second general population study, Peterlin et al evaluated the prevalence of migraine in those with TBO using measured body mass indices.14 A total of 15,531 reproductive-age participants, ranging from 20 to 55 years of age, who self-reported migraine or severe headaches were evaluated. TBO was estimated using measured height and weight to calculate the BMI. In addition Ab-O was evaluated based on a WC. As in the Ford study,32 the odds of migraine or severe headache was increased by approximately

39% in woman of reproductive age with TBO (OR 1.39; CI: 1.24-1.56), with a similar result in men of the same age group (OR 1.38; CI: 1.20-1.59). These associations were independent of abdominal obesity for both genders. In addition a very similar association Methane monooxygenase was found between abdominal obesity and migraine or severe headaches in women. In those women of reproductive-age with abdominal obesity, the odds of migraine or severe headache was increased by approximately 39%, (OR 1.39; CI: 1.25-1.56); and this association was independent of TBO. In contrast, while the odds of migraine or severe headache were also increased in men with abdominal obesity, (OR 1.30; CI: 1.13-1.48), it was not independent of TBO.14 Confirmatory studies using ICHD criteria and measured body mass indices are needed. 1 The prevalence of migraine may be increased in those who are underweight as estimated by TBO. Obesity and Migraine in Peri- and Postmenopausal Age.