In: Gauthier S, Scheltens P, Cummings J L, eds. Alzheimer’s Disease and Related … What is amnestic MCI? Amnestic MCI was defined by Petersen et al2 in the context of a natural observation study, which demonstrated a rate of conversion

to AD that was well above the incidence of agematched populations. The original amnestic MCI criteria are as follows2: Memory complaint, preferably corroborated by an informant. Memory impairment relative to age and education matched normal subjects. Relatively normal general cognitive function. now Largely intact activities of daily living (ADL). Not demented. A more recent subclassification of MCI has been proposed by Petersen3 on the basis of findings Inhibitors,research,lifescience,medical from cognitive testing in larger number of subjects: Amnestic or single memory MCI. Multiple domain MCI. The first two groups (single memory MCI and multiple domain [including memory] MCI) seem to share the same risk of conversion to AD, whereas the Inhibitors,research,lifescience,medical third group (single non-memory-domain MCI) may be a prodrome to the nonAD dementias. For the purpose of RCTs, operational criteria with specific inclusion/exclusion

criteria have been specified. The criteria for the study completed by the Alzheimer Disease Cooperative Study comparing donepezil with tocopherol and placebo4 are Inhibitors,research,lifescience,medical listed in Table II; this study will be referred to in this monograph as the Memory Impairment Study (MIS). Although not fully analyzed Inhibitors,research,lifescience,medical and published, entry criteria for the twin studies (with and without mag_ netic resonance imaging [MRI]) comparing galantamine and placebo are available5 and are summarized in Table III. The Investigation into the Delay to Diagnosis of AD with Exelon (rivastigmine) (InDDEx) study is not yet completed, but the entry criteria of this 4-year RCT comparing rivastigmine with placebo have been published.6 These are listed in Table IV for purposes of comparison between the Inhibitors,research,lifescience,medical MIS, the galantamine studies, and the InDDEx study Table II. Entry criteria into the Alzheimer Disease Cooperative Study

(here referred to as the Memory Impairment Study [MIS]). ADL, activities of daily living; CDR, Clinical Dementia Rating; MMSE, Mini-Mental-State Examination; CT, computed tomography; MRI, magnetic … Table III. Entry criteria in the galantamine studies. ADL, activities of daily living; CDR, Clinical Dementia Rating; NYU, Brefeldin_A New York University. Modified from reference 5: Gold M, Wang D, Truyen L. Galantamine for the treatment of mild cognitive impairment: 2 double-blind, … Table IV. Entry criteria in the Investigation in the Delay to Diagnosis of AD with Exelon (InDDEx) study CDR, Clinical Dementia Rating; NYU, New York University Modified from reference 6: Feldman H, Scheltens P, Scarpini E, et al. Behavioral symptoms in mild cognitive …