“
“A human being born without heart and head, i.e., the acardius/acranius malformation, has been described since antiquity. Superstition and fear made it a mystical disorder, a sign of

God’s wrath. The inquisition ruled that acranic infants should not be baptized and located the soul in the brain. Acardia was not associated with twin gestation until the reports of Mery in 1720 and Winslow in 1740. In 1850, Meckel identified the pathogenetic mechanism as reversed perfusion due to large arterio-arterial and veno-venous anastomoses; he believed the heart would fail to develop or arrest during development, and the acardiac fetus would be maintained by arterial https://www.selleckchem.com/products/mln-4924.html perfusion from the pump twin. In 1859, Claudius articulated that after normal initial development, the heart degenerates when reversed flow in the aorta leads to thrombosis. Today, it is assumed that both mechanisms may exist. With the advent of prenatal ultrasound diagnosis and radiofrequency ablation of the acardiac twin’s circulation, it became possible to save the pump twin.”
“A major priority in many low and middle income countries is the eradication of infectious diseases through an effective vaccination Smad3 signaling program. However, the lack of reliable infrastructure,

equipment and support often prove to be significant barriers in such countries. In particular, unreliable electric power and refrigeration equipment are major concerns and this has prompted research into the development of passive cold storage devices (PCDs) that are not dependent on electric power and can maintain cold temperatures for extended periods of time using a passive medium such as ice. The development of PCDs is in its early stages, and there are many open questions including how they should be sized, the interaction between price and device size, and how often they should be replenished. So far, these types of questions have not been systematically Selleckchem Citarinostat analyzed anywhere in the research literature, and this paper describes

a model to address these issues in order to better guide the development of PCDs in the near future. This paper examines actual use cases with real data from a representative country, and presents a model that captures the various tradeoffs that must be considered in developing a suitable PCD while providing guidance on what would constitute a useful, robust and economical design.”
“Patients with first venous thromboembolism (VTE) and high factor VIII (FVIII) are at increased risk of recurrence. It is unknown whether these patients benefit from prolonged secondary thrombophrophylaxis. In a prospective trial patients with first spontaneous VTE and FVIII levels > 230 IU/dl were randomized to discontinue vitamin K Antagonist (VKA) after 6 months or to continue VKA for additional 24 months.