Conversely, down regulation of annexin II has been reported in prostate carcinoma, esophageal carcinoma and laryngeal squamous cell carcinoma. For that reason, the purpose of annexin II in cancer invasion and metastasis remains un clear. In hepatocellular carcinoma, annexin II is fre quently up regulated both on the mRNA along with the protein degree, hepatitis B virus induced hepatocellular carcinoma demonstrates increased annexin II ex pression amounts in contrast to hepatitis C virus induced hepatocellular carcinoma. The up regulation of annexin II expression in pancreatic, colorectal, and brain tumors was also straight correlated with innovative clinical stage. Higher annexin II expression was observed in metastatic breast cancer and colon cancer cells compared using the non metastatic cells.
A latest review applying a proteomic strategy investigating the secretome from the gastric cancer cell line SGC7901 identified annexin A2 as being a secreted phosphoprotein. full article Previous examine has indicated that annexin II overexpres sion in gastric cancer was additional frequently observed in in testinal form tumor cases, lymph node metastasis and venous invasion. Together these research propose that annexin II has likely diagnostic and prognostic value being a therapeutic target to inhibit cancer progression and metastasis which must be additional examined. Accumulating proof suggests that interactions be tween annexin II and its binding proteins play an im portant purpose while in the tumor microenvironment and act with each other to enhance cancer metastasis. The listing of annexin II interacting proteins incorporates t PA, p11 professional tein, tenascin C and cathepsin B.
Annexin and S100 pro teins typically type complexes. Annexin II interacts with S100A4 likewise as S100A10. It really is extremely expressed in endothelial cells and is overexpressed in breast and colon cancer, by which it’s been implicated in invasive habits. In each B 1 cells and stimulated B 2 cells, annexin II and S100A6 existed as Ca dependent com SNS032B plexes. It’s also been reported that a powerful asso ciation is in between the presence of annexin II within the plasma membrane and substantial levels of cytoplasmic S100A6 of pancreatic cancer cells. In MKN28 cells and major gastric carcinomas, annexin II kinds a com plex with calpactin I light chain which belongs towards the S a hundred family as EF hand protein and is associated with cell differentiation, malignant transformation and cell cycle control.
To reveal the association amid expression of annexin II and S100A6 in gastric cancer, we also studied the ex pression of S100A6 and, as we anticipated, S100A6 was up regulated in gastric cancer tissues in contrast to nor mal gastric tissues. S100A6 protein ranges have been observed to correlate significantly with the prognosis of gastric can cer. S100A6 was discovered to be extensively expressed in gastric carcinomas and its expression could contribute to your progression of carcinomas and be valuable in predicting the prognosis of gastric cancer.