Design: A prospective and observational study of patients after traumatic injuries of lower extremities. Assessments were performed at baseline and 3 months later. Setting: In-patients and out-patients

in two university hospitals in Taiwan. Participants: A convenience sample of 109 subjects were evaluated and 94 (86%) were followed. Interventions: Not applicable. Main Outcome Measure(s): Assessments of responsiveness with distribution-based approach (effect size, standardized response mean [SRM], minimal detectable change) and anchor-based approach (receiver’s operating curve analysis, ROC analysis). Results: LEFS and physical component score (PCS) of SF-36 were all responsive to global improvement, with fair-to-good accuracy in discriminating between participants with and without improvement. The area under curve gained by ROC analysis for LEFS and SF-36 PCS was similar (0.65 vs. 0.70, p = 0.26). ACY-738 manufacturer Conclusions: Our findings revealed comparable responsiveness of LEFS and PCS of SF-36 in a sample of subjects with traumatic injuries of lower limbs. Either type of functional measure would

be suitable for use in clinical trials where improvement in function was an endpoint of interest. (C) 2014 Elsevier Ltd. All rights reserved.”
“Objective: Selleck NCT-501 To analyze the prognostic factors related to the recurrence rate of vulvar cancer.\n\nMethods: Retrospective study of 87 Ulixertinib ic50 patients diagnosed of vulvar squamous cell carcinoma diagnosed at a tertiary hospital in Madrid between January 2000 and December 2010.\n\nResults: The pathological mean tumor size was 35.1 +/- 22.8 mm, with stromal invasion

of 7.7 +/- 6.6 mm. The mean free margin after surgery was 16.8 +/- 10.5 mm. Among all patients, 31 (35.6%) presented local recurrence (mean time 10 months; range, 1 to 114 months) and 7(8%) had distant metastases (mean time, 5 months; range, 1 to 114 months). We found significant differences in the mean tumor size between patients who presented a relapse and those who did not (37.6 +/- 21.3 mm vs. 28.9 +/- 12.1 mm; p=0.05). Patients with free margins equal or less than 8 mm presented a relapse rate of 52.6% vs. 43.5% of those with free margin greater than 8 mm (p=0.50). However, with a cut-off of 15 mm, we observed a local recurrence rate of 55.6% vs. 34.5%, respectively (p=0.09). When the stromal invasion cut-off was >4 mm, local recurrence rate increased up to 52.9% compared to 37.5% when the stromal invasion was <= 4 mm (p=0.20).\n\nConclusion: Tumor size, pathologic margin distance and stromal invasion seem to be the most important predictors of local vulvar recurrence. We consider the cut-off of 35 mm of tumor size, 15 mm tumor-free surgical margin and stromal invasion >4 mm, high risk predictors of local recurrence rate.”
“The use of autologous fat grafting is ideal in breast reconstruction.