Editorial support for the final version of this article, comprisi

Editorial support for the final version of this article, comprising of language editing, content checking, formatting, and referencing was provided by Sophie Rushton-Smith, Ph.D. Dr Boonen is senior clinical investigator of the

Fund for Scientific Research, Flanders, Belgium (F.W.O.-Vlaanderen) and BVD-523 cost holder of the Leuven University Chair in Metabolic Bone Diseases. Funding GLOW is sponsored by a grant from The Alliance for Better Bone Health (Procter & Gamble Pharmaceuticals XAV-939 datasheet and sanofi-aventis). Conflicts of interest Ethel S Siris—consulting fees: Amgen, Lilly, Merck, Procter & Gamble, sanofi-aventis, Novartis. Stephen Gehlbach—research and salary support: The Alliance for Better Bone Health (Procter & Gamble Pharmaceuticals, sanofi-aventis). Jonathan D Adachi—research Sepantronium solubility dmso and salary support: Amgen, Astra Zeneca, Eli Lilly, GlaxoSmithKline, Merck, Novartis, Nycomed, Pfizer, Procter & Gamble, Roche, sanofi-aventis, Servier, Wyeth, Bristol-Myers Squibb; clinical trials: Amgen, Eli Lilly, GlaxoSmithKline, Merck, Novartis, Pfizer, Procter & Gamble, Roche, sanofi-aventis, Wyeth, Bristol-Myers Squibb. Steven Boonen—research grants: Amgen, Eli Lilly, Novartis, Pfizer, Procter & Gamble, sanofi-aventis, Roche, GlaxoSmithKline; Speakers’ bureau:

Amgen, Eli Lilly, Merck, Novartis, Procter & Gamble, sanofi-aventis, Servier; honoraria: Amgen, Eli Lilly, Merck, Novartis, Procter & Gamble, sanofi-aventis, Servier; consultant/advisory board: Amgen, Eli Lilly, Merck, Novartis, Procter & Gamble, sanofi-aventis, Servier. Roland Chapurlat—research grants: French Ministry of Health, Servier, Lilly, Procter & Gamble; honoraria from Servier, Novartis, Lilly, Roche, sanofi-aventis, Maxence Pharma; consultant/advisory board: Servier, Nycomed, Novartis, Maxence Pharma. Juliet Compston—consultancy: Servier, Shire, Nycomed, Novartis, Amgen, Procter & Gamble, Wyeth, Pfizer, The Alliance much for Better Bone Health, Roche, GlaxoSmithKline; speaking engagements (with reimbursement, travel and accommodation): Servier, Procter & Gamble, Eli

Lilly; research grants: Servier R&D, Procter & Gamble. Cyrus Cooper—consultancy and lecturing: Amgen, The Alliance for Better Bone Health, Eli Lily, Merck Sharp and Dohme, Servier, Novartis, Roche-GSK. Pierre Delmas: None. Adolfo Díez-Pérez—honoraria: Novartis, Eli Lilly, Amgen, Procter & Gamble, Roche; Expert witness for Merck—consultant/advisory board: Novartis, Eli Lilly, Amgen, Procter & Gamble; research and salary support: Novartis, Eli Lilly, Amgen, Procter & Gamble, Roche. Frederick H Hooven—research and salary support: The Alliance for Better Bone Health (Procter & Gamble Pharmaceuticals, sanofi-aventis). Andrea LaCroix—research and salary support: The Alliance for Better Bone Health (Procter & Gamble Pharmaceuticals and sanofi-aventis).

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