However, a febrile urinary tract infection developed in 16 patients (4.4% overall, p <0.0001.) at a mean age of 9.3 months. Voiding cystourethrogram performed in these 16 patients revealed vesicoureteral reflux in 12. Of all the patients with a urinary tract infection who were ultimately observed to have vesicoureteral reflux (including those initially screened and those discovered to have reflux after

a urinary tract infection) the laterality of hydronephrosis, grade of reflux and laterality of reflux were comparable.

Conclusions: In patients with a history of prenatal hydronephrosis who are observed to have postnatally persistent grade II hydronephrosis identification of vesicoureteral reflux and use of prophylactic antibiotics significantly reduce the risk of febrile urinary tract infection. Therefore, we recommend that patients with a history of prenatal hydronephrosis and postnatally persistent hydronephrosis CB-839 mw be screened with voiding cystourethrography early in life, and be placed on prophylactic antibiotics until the screening results are known.”
“Purpose: We estimated the spectrum and risk factors for daytime urinary incontinence in school-age children.

Materials BVD-523 and

Methods: A validated, reproducible, parent administered daytime incontinence questionnaire was distributed to randomly selected school children. The questionnaire elicited information on demographic factors, prenatal and developmental HSP90 factors, and bowel and urinary

history. The spectrum of daytime urinary incontinence was measured by recording the frequency and amount of incontinence.

Results: Parents of 2,856 children (mean age 7.3 years) completed the questionnaire. Overall 16.9% reported any daytime urinary incontinence in the previous 6 months, with 64% of cases being very mild, 14.8% mild, 11.6% moderate and 9.6% severe. There was low agreement between frequency and amount of incontinence (weighted kappa 0.03) but, risk factors were similar. Independent risk factors were nocturnal enuresis (OR 7.2, 95% CI 3.4 to 15.2), female gender (5.4, 2.6 to 11.1), social concerns (3.4, 1.4 to 8.3), urinary tract infection (5.6, 2.0 to 15.6) and encopresis (3.3, 1.4 to 7.7). Expressed as population attributable risk, 36% of moderate to severe daytime incontinence can be attributed to encopresis, nocturnal enuresis, social concerns’, female gender or urinary tract infection. Urinary tract infection was a risk factor for boys but not for girls (interaction p <0.01).

Conclusions: Daytime urinary incontinence in children is a common but heterogeneous disorder, Episodes may be frequent or major or both but appear to share the same causal pathway. Given the risk factors identified, interventions should target endogenous/physiological and environmental factors.