Patients were followed

for a median 3.5 years (interquartile range = 2.1-5.5). Compared to no history of smoking, current smoking was associated with worse pre-HSCT pulmonary function tests (P<0.02 in each case), more days hospitalization high throughput screening compounds (46.2 days versus 25.7 days, P=0.025), and poorer overall survival (hazard ratio (HR) 1.88; 95% CI 1.09-3.25). Results were similar after multivariate adjustment, although the association with overall survival attenuated slightly (HR=1.75; 95% CI 1.00-3.06). Current smoking appears to adversely affect the number of days hospitalized post HSCT and overall survival. Translational research focused on interventions to promote tobacco cessation may lead to improved HSCT outcomes. Bone Marrow Transplantation (2011) 46, 285-290; doi: 10.1038/bmt.2010.113; published online 17 May 2010″
“Acetogenic bacteria are able to grow autotrophically on hydrogen and carbon dioxide by using the acetyl coenzyme A (acetyl-CoA) pathway. Acetate is the

end product of this reaction. In contrast to the fermentative route of acetate production, which shows almost no fractionation of carbon isotopes, the acetyl-CoA pathway has been reported to exhibit a preference for light carbon. In Acetobacterium woodii the isotope fractionation selleck inhibitor factor (epsilon) for C-13 and C-12 has previously been reported to be epsilon = -58.6 parts per thousand. To investigate whether such a strong fractionation is a general feature of acetogenic bacteria, we measured the stable carbon isotope fractionation factor of 10 acetogenic strains grown on H-2 and CO2. The average fractionation factor was epsilon(TIC) = -57.2 parts per thousand for utilization of Selleck Barasertib total inorganic carbon

and epsilon(acetate) = -54.6 parts per thousand for the production of acetate. The strongest fractionation was found for Sporomusa sphaeroides (epsilon(TIC) = -68.3 parts per thousand), the lowest fractionation for Morella thermoacetica (epsilon(TIC) = -38.2 parts per thousand). To investigate the reproducibility of our measurements, we determined the fractionation factor of 21 biological replicates of Thermoanaerobacter kivui. In general, our study confirmed the strong fractionation of stable carbon during chemolithotrophic acetate formation in acetogenic bacteria. However, the specific characteristics of the bacterial strain, as well as the cultural conditions, may have a moderate influence on the overall fractionation.”
“A large group of bacterial small regulatory RNAs (sRNAs) use the Hfq chaperone to mediate pairing with and regulation of mRNAs. Recent findings help to clarify how Hfq acts and highlight the role of the endonuclease RNase E and its associated proteins (the degradosome) in negative regulation by these sRNAs. sRNAs frequently uncouple transcription and translation by blocking ribosome access to the mRNA, allowing other proteins access to the mRNA.