Res Microbiol 2000, 151:487–491.CrossRefPubMed 38. Israel DA, Lou AS, Blaser MJ: Characteristics of Helicobacter pylori natural transformation. FEMS Microbiol Lett 2000, 186:275–280.CrossRefPubMed 39. Kobayashi I: Homologous recombination and sex as a strategy against selfish genes attacking the genome. Ann N Y Acad Sci 1999, 870:354–356.CrossRefPubMed 40. Kusano K, Naito T, Handa N, Kobayashi I: Restriction-modification

systems as genomic parasites in competition for specific sequences. Proc Trametinib mouse Natl Acad Sci USA 1995, 92:11095–11099.CrossRefPubMed 41. Naito T, Kusano K, Kobayashi I: Selfish behavior of restriction-modification systems. Science 1995, 267:897–899.CrossRefPubMed 42. Bjorkholm B, Sjolund M, Falk PG, Berg OG, Engstrand L, Andersson DI: Mutation frequency and biological cost KU-57788 molecular weight of antibiotic resistance in. Helicobacter pylori 2001, 98:14607–14612. 43.

Wirth T, Wang X, Linz B, Novick RP, Lum JK, Blaser M, Morelli G, Falush D, Achtman M: Distinguishing human ethnic groups by means of sequences from Helicobacter pylori : lessons from Ladakh. Proc Natl Acad Sci USA 2004, 101:4746–4751.CrossRefPubMed 44. Takahashi N, Naito Y, Handa N, Kobayashi I: A DNA methyltransferase can protect the genome from postdisturbance attack by a restriction-modification gene complex. J Bacteriol 2002, 184:6100–6108.CrossRefPubMed 45. Alm RA, Trust TJ: Analysis of the genetic diversity of Helicobacter pylori : the tale of two genomes. J Mol Med 1999, 77:834–846.CrossRefPubMed 46. Salama N, Guillemin K, McDaniel TK, Sherlock G, Tompkins L, Falkow S: A whole-genome microarray

reveals genetic diversity among Helicobacter pylori strains. Proc Natl Acad Sci USA 2000, 97:14668–14673.CrossRefPubMed 47. Lehours P, Dupouy S, Chaineux J, Ruskone-Fourmestraux A, Delchier JC, Morgner A, Megraud Cediranib (AZD2171) F, Menard A: Genetic diversity of the HpyC1I restriction modification system in Helicobacter pylori. Res Microbiol 2007, 158:265–271.CrossRefPubMed 48. Humbert O, Salama NR: The Helicobacter pylori HpyAXII restriction-modification system limits exogenous DNA uptake by targeting GTAC sites but shows asymmetric conservation of the DNA methyltransferase and restriction endonuclease components. Nucleic Acids Res 2008. 49. Kobayashi I, Nobusato A, Kobayashi-Takahashi N, Uchiyama I: Shaping the genome – restriction-modification systems as mobile genetic elements. Curr Opin Genet Dev 1999, 9:649–656.CrossRefPubMed 50. Kobayashi I: Behavior of restriction-modification systems as selfish mobile elements and their impact on genome evolution. Nucleic Acids Res 2001, 29:3742–3756.CrossRefPubMed 51. Kobayashi I: Restriction-Modification systems as minimal forms of life. Restriction endonucleases (Edited by: Pingoud A). Berlin: Springer-Verlag 2004, 19–62. 52.