The initiative pursues the principles of comprehensive transparency and publicity. Dr. Dotson introduced some of the working group’s recent recommendations on genetic variants which have potential benefit for common disease prevention or which predict response to drug treatment. He also drew attention to GAPP Finder, launched by OPHG
in 2010, which provides a continually updated database, tracking the growing number of genetic tests and genomic applications under development or available for use in clinical and public health practice. Robert Green (Harvard-Partners Center for Personalized Genetic Medicine, USA) first gave some insights into the Risk Evaluation and Education for Alzheimer’s Disease (REVEAL) study, in which adult offspring of Alzheimer’s disease patients were offered testing for the apolipoprotein E (Apo E) polymorphism. VX-680 solubility dmso At this point, Dr. Green addressed the major issue of the symposium—the perception and behavioral outcome of predictive genetic testing. The REVEAL study showed that testing had minimal psychological impact and even HDAC inhibitor provoked behavioral changes (for example, intake of vitamins and other supplements or the taking out of new health insurances)
in persons to whom the information that they were carriers of the high-risk Apo E 4-allele had been disclosed, although no buy NSC23766 effective preventive measures for Alzheimer’s disease exist today. Dr. Green pointed out that, in the public and scientists’ view, the road to “healthy aging” starts with self-awareness and self-responsibility towards disease prevention. To this end, action is needed early in life. However, solid scientific evidence must be presented to support the recommendations and actions chosen. Dr. Green also mentioned ongoing intervention trials to establish the effect of attained
genetic risks information for common diseases, e.g., type 2 diabetes or obesity. He also mentioned the forthcoming MedSeq study, which is the first clinical trial ever funded by the National Institutes of Health (NIH) to empirically study the use of whole genome sequencing in the practice of medicine and which is expected to meet the challenges of disclosure of large-scale genomic data. the Dr. Green finalized by citing a statement given by the US Preventive Services Task Force (Petitti et al. 2009): “Decision makers do not have the luxury of waiting for certain evidence. Even though evidence is insufficient, the clinician must still provide advice, patients must make choices, and policymakers must establish policies.” Martina Cornel (VU University Medical Center Amsterdam, The Netherlands) spoke about the problems facing the application of genomics in the prevention of common diseases and focused on recently published policy statements by the European Society of Human Genetics regarding direct-to-consumer genetic testing and genetic testing for common disorders. Dr.