For example, in boys and girls combined, in our most completely adjusted model, a doubling TPX-0005 concentration in 25(OH)D2 was associated with a 0.05SD decrease in BMDC.

Whereas 25(OH)D2 was unrelated to Tideglusib order periosteal circumference in minimally adjusted analyses, there was a weak positive association in more fully adjusted models, to a similar degree, in boys and girls. In minimally adjusted analyses, 25(OH)D2 was inversely related to cortical bone area, BMCC, endosteal adjusted for periosteal circumference and cortical thickness in females, but this was not seen after more complete adjustment. Table 3 Associations between plasma concentration of 25(OH)D2 and pQCT parametres     Vitamin 25(OH)D2 Minimally adjusted, N = 3,579 Selleckchem Oligomycin A (males=1,709) Anthropometry-adjusted, N = 3,579 (males=1,709) Anthropometry-, SES- and PA-adjusted, N = 2,247 (males=1,203) Beta 95% CI P value (sex) Beta 95% CI P value (sex) Beta 95% CI P value (sex) Cortical bone mineral density Male −0.055 (−0.099, -0.010) 0.74 −0.048 (−0.091, -0.005) 0.89 −0.049 (−0.101, 0.004) 0.98 Female −0.048 (−0.082, -0.014) −0.046 (−0.078, -0.014) −0.048 (−0.089, -0.008) ALL −0.051 (−0.084, -0.017) −0.047 (−0.079, -0.015) −0.048 (−0.087, -0.011) Cortical bone area Male −0.006 (−0.055, 0.043) 0.04 0.013 (−0.021, 0.047) 0.32 0.006 (−0.038, 0.049) 0.90 Female −0.054 (−0.095, -0.013) −0.003 (−0.030, of 0.025) 0.003 (−0.033, 0.039) ALL −0.033 (−0.071, 0.006) 0.004 (−0.022, 0.031) 0.004 (−0.029, 0.037) Cortical bone mineral content

Male −0.021 (−0.074, 0.031) 0.05 0.000 (−0.035, 0.036) 0.37 −0.007 (−0.053, 0.039) 0.93 Female −0.069 (−0.113, -0.026) −0.015 (−0.044, 0.015) −0.009 (−0.047, 0.028) ALL −0.048 (−0.089, -0.007) −0.008 (−0.036, 0.020) −0.008 (−0.044, 0.027) Periosteal circumference Male 0.018 (−0.026, 0.062) 0.08 0.035 (0.002, 0.067) 0.82 0.037 (−0.007, 0.080) 0.86 Female −0.021 (−0.061, 0.021) 0.031 (0.000, 0.063) 0.041 (0.003, 0.079) ALL −0.004 (−0.040, 0.032) 0.033 (0.005, 0.060) 0.039 (0.006, 0.075) Endosteal adjusted for periosteal circumference Male 0.026 (−0.012, 0.063) 0.14 0.01 (−0.024, 0.044) 0.22 0.017 (−0.025, 0.058) 0.71 Female 0.052 (0.021, 0.082) 0.029 (0.001, 0.057) 0.024 (−0.009, 0.059) ALL 0.040 (0.011, 0.069) 0.021 (−0.007, 0.047) 0.021 (−0.010, 0.053) Cortical thickness Male −0.031 (−0.085, 0.025) 0.07 −0.018 (−0.065, 0.030) 0.24 −0.029 (−0.088, 0.029) 0.73 Female −0.078 (−0.123, -0.033) −0.044 (−0.082, -0.006) −0.039 (−0.089, 0.