When progesterone was injected 4 h before restraint, progesterone

When progesterone was injected 4 h before restraint, progesterone eliminated the effects of restraint. In contrast, progesterone 30 min before restraint offered no protection. Effects of progesterone 1 h before restraint were equivocal allowing the suggestion that less than 4 h of progesterone priming might be sufficient. In the second experiment,

PARP inhibitor the synthetic progestin, medroxyprogesterone, was shown to mimic effects of progesterone in preventing effects of restraint. Finally, the progesterone receptor antagonist, RU486, attenuated progesterone’s protection against restraint. These findings offer evidence that ligand-activated progesterone receptor mechanisms contribute to the maintenance of lordosis behavior in the presence of mild stress. (C) 2011 Elsevier Inc. All rights reserved.”
“Royal jelly contains numerous components, including proteins. Major royal jelly protein (MRJP) 1 is the most abundant protein among the soluble royal jelly proteins. In its physiological state, MRJP 1 exists MK-1775 price as a monomer and/or oligomer.

This study focuses the molecular characteristics and functions of MRJP 1 oligomer. MRJP 1 oligomer purified using HPLC techniques was subjected to the following analyses. The molecular weight of MRJP 1 oligomer was found to be 290 kDa using blue native-PAGE. MRJP 1 oligomer was separated into 55 and 5 kDa spots on 2-D blue native/SDS-PAGE. The 55 kDa protein was identified as MRJP 1 monomer by proteome analysis, whereas the 5 kDa protein was identified as Apisimin by N-terminal amino acid sequencing, and this protein may function as a subunit-joining protein within MRJP 1 oligomer. We also found that the oligomeric form included noncovalent bonds and was stable under heat treatment at 56 C. Furthermore, MRJP 1 oligomer dose dependently enhanced and sustained cell proliferation in the human lymphoid cell line Jurkat. In conclusion, MRJP 1 oligomer is a heat-resistant protein PD-1/PD-L1 Inhibitor 3 comprising MRJP 1 monomer and Apisimin, and has cell proliferation activity. These findings will contribute to further studies analyzing

the effects of MRJP 1 in humans.”
“Chronic obstructive pulmonary disease (COPD) poses a significant economic burden on society, and a substantial portion is related to exacerbations of COPD. A literature review of the direct and indirect costs of COPD exacerbations was performed. A systematic search of the MEDLINE database from 1998-2008 was conducted and supplemented with searches of conference abstracts and article bibliographies. Articles that contained cost data related to COPD exacerbations were selected for in-depth review. Eleven studies examining healthcare costs associated with COPD exacerbations were identified. The estimated costs of exacerbations vary widely across studies: $88 to $7,757 per exacerbation (2007 US dollars).

Of these, 72 patients finally underwent a PD and were randomized

Of these, 72 patients finally underwent a PD and were randomized to either a retrocolic or antecolic reconstruction of the gastro/duodenojejunostomy. All patients underwent the standard Whipple’s or a pylorus preserving pancreaticoduodenectomy (PPPD), and the randomization was stratified according to the type of PD done. DGE was assessed clinically using the Johns Hopkins criteria (Yeo et al. in Ann Surg 218: 229-37, 1993). In

patients suspected to have DGE, mechanical causes were excluded by imaging and/or endoscopy. Occurrence of DGE was the primary endpoint, whereas duration of hospital stay and occurrence of intra-abdominal complications were the secondary end points.\n\nThe antecolic and retrocolic groups were comparable with regard to patient

demographics, diagnosis, 26s Proteasome structure and other preoperative, intraoperative, and postoperative factors. Overall, DGE occurred in 21 patients (30.9%). There was no significant difference in the incidence of DGE in the antecolic vs. the retrocolic group (34.4% vs. 27.8%; p = 0.6). On univariate analysis, older age, use of octreotide, and intra-abdominal complications were significantly associated with the occurrence of DGE; however, on a multivariate analysis, only age was found to be significant (p = 0.02). The mean postoperative stay was longer among patients who developed DGE (21.9 +/- 9.3 days vs. 13 +/- 6.9 days; p = 0.0001).\n\nDelayed gastric emptying is a cause of significant morbidity and prolongs the selleck chemical duration of hospitalization following pancreaticoduodenectomy. The incidence of DGE does not appear to be related to the method of reconstruction (antecolic or retrocolic). Older age may be a risk factor for its occurrence.”
“High molecular weight hyaluronan (HA) is widely used in the treatment of osteoarthritis (OA) and rheumatoid arthritis (RA) by intra-articular injection. However,

comparative studies of HA actions on catalytically activated cartilages in different pathologic conditions have rarely been investigated. This Study was aimed to compare the inhibitory effects of HA on nitric oxide (NO) production by COOH-terminal heparin-binding fibronectin fragment (HBFN-f) between normal and diseased cartilages. When mTOR inhibitor articular cartilage explants from normal, OA, or RA joints were incubated with HBFN-f, the RA and OA cartilages produced higher levels of NO compared with normal cartilage. Pretreatment with 2700 kDa HA resulted in significant suppression of HBFN-f-stimulated NO production in OA and RA cartilages. While CD44 was up-regulated in OA and RA cartilages, anti-CD44 antibody reversed HA inhibition of HBFN-f action in those cartilages. The present results clearly demonstrated that HA blocked HBFN-f actions in OA and RA cartilages through interaction with CD44.

The herein described dissociated culture can be utilized

The herein described dissociated culture can be utilized this website as in vitro model to screen interactions between cells of the IC and surface modifications of the electrode.”
“Objective: To reevaluate ovarian hyperstimulation syndrome (OHSS) prevention techniques and provide a classification system for grading OHSS and evidence-based treatment strategies for preventing OHSS.\n\nDesign: A literature search was conducted in PubMed for articles

published in the last 5 years using the keywords “controlled ovarian stimulation,” “controlled ovarian hyperstimulation,” “ovarian hyperstimulation syndrome,” “OHSS,” “prevention,” “chorionic gonadotropin,” “hCG,” “GnRH agonist,” “GnRH antagonist,” “coasting,” and “cryopreservation.” We reviewed randomized controlled trials (RCTs), retrospective studies, pilot studies, case studies, reviews, and meta-analyses.\n\nResult(s): There is a shortage of large, prospective RCTs reporting OHSS prediction and prevention strategies. Our review

showed that risk factors such as antral follicle count and baseline anti-Mullerian hormone level may identify women at high OHSS risk. Preventative strategies that appear highly effective at reducing or preventing OHSS include GnRH antagonist protocols and the use of GnRH agonists to trigger final oocyte maturation. Moreover, alternative therapies, find more such as dopamine receptor agonists (Cabergoline), have also emerged as potential new treatment modalities in the management of this disease.\n\nConclusion(s): These findings suggest that current treatment guidelines

should be updated to incorporate findings from recent literature that show that GnRH antagonist protocols consistently reduce OHSS and that GnRH agonist triggering has considerable promise in preventing OHSS, although further RCTs will be needed to confirm this. (Fertil Steril(R) 2010;94:389-400. (C) 2010 by American Society for Reproductive Medicine.)”
“Background\n\nVarious rehabilitation treatments may be offered following carpal tunnel syndrome (CTS) surgery. The effectiveness of these interventions remains unclear.\n\nObjectives\n\nTo ABT 737 review the effectiveness of rehabilitation following CTS surgery compared with no treatment, placebo, or another intervention.\n\nSearch methods\n\nOn 3 April 2012, we searched the Cochrane Neuromuscular Disease Group Specialized Register (3 April 2012), CENTRAL (2012, Issue 3), MEDLINE (January 1966 to March 2012), EMBASE (January 1980 to March 2012), CINAHL Plus (January 1937 to March 2012), AMED (January 1985 to April 2012), LILACS (January 1982 to March 2012), PsycINFO (January 1806 to March 2012), PEDRO (29 January 2013) and clinical trials registers (29 January 2013).

Infection of macrophages with zmp1-deleted Mtb triggered activati

Infection of macrophages with zmp1-deleted Mtb triggered activation of the inflammasome, resulting in increased JNK-IN-8 IL-1 beta secretion, enhanced maturation of Mtb containing phagosomes, improved mycobacterial clearance by macrophages, and lower bacterial burden in the lungs of aerosol-infected mice. Thus, we uncovered a previously masked role for IL-1 beta in the control of Mtb and a mycobacterial system that prevents inflammasome and, therefore, IL-1 beta activation.”
“The ruthenium (II) polypyridyl

complexes (RPC), Delta-[(phen)(2)Ru(tatpp)]Cl-2 (Delta-[3]Cl-2) and Delta Delta-[(phen)(2)Ru (tatpp)Ru(phen)(2)]Cl-4(Delta Delta-[4]Cl-4, are a new generation of metal-based antitumor agents. These RPCs bind DNA via intercalation of the tatpp ligand, which itself is redox-active and is easily reduced at biologically relevant potentials. We have previously shown that RPC 4(4+) cleaves DNA when reduced by glutathione to a radical species and that this DNA cleavage is potentiated under hypoxic conditions in vitro. Here, we show that 3(2+) also

exhibits free radical-mediated DNA cleavage in vitro and that 3(2+) and 4(4+) both exhibit selective cytotoxicity toward cultured malignant cell lines and marked inhibition of tumor growth in vivo. The murine acute toxicity of RPCs3(2+) and 4(4+) (maximum tolerable doses similar to 65 mu mol/kg) is comparable with that for cisplatin (LD50 similar to 57 mu mol/kg), but unlike cisplatin, RPCs are generally cleared from the body unchanged via renal excretion without selleck compound appreciable

metabolism or nephrotoxic side effects. RPCs3(2+) and 4(4+) are shown to suppress growth of human non-small cell lung carcinoma (similar to 83%), show potentiated cytotoxicity 3-MA cost in vitro under hypoxic conditions, and induce apoptosis through both intrinsic and extrinsic pathways. The novel hypoxia-enhanced DNA cleavage activity and biologic activity suggest a promising new anticancer pharmacophore based on metal complexes with aromatic ligands that are easily reduced at biologically accessible potentials. (c) 2013 AACR.”
“Hunter syndrome is a rare, X-linked disorder caused by a deficiency of the lysosomal enzyme iduronate-2-sulfatase. In the absence of sufficient enzyme activity, glycosaminoglycans accumulate in the lysosomes of many tissues and organs and contribute to the multisystem, progressive pathologies seen in Hunter syndrome. The nervous, cardiovascular, respiratory, and musculoskeletal systems can be involved in individuals with Hunter syndrome. Although the management of some clinical problems associated with the disease may seem routine, the management is typically complex and requires the physician to be aware of the special issues surrounding the patient with Hunter syndrome, and a multidisciplinary approach should be taken.

Preceding the instantaneous removal of the bar with a flash at on

Preceding the instantaneous removal of the bar with a flash at one end resulted in a motion percept away from the flash. If this flash and the bar’s removal overlapped in time, it appeared that the bar was removed towards the flash (reverse ILM). Independent of the motion type, brain responses indicated activations in areas associated with motion (MT+), endogenous and exogenous attention (intraparietal sulcus, frontal eye fields, and ventral frontal cortex), and response selection (ACC). ILM

was associated with lower learn more percept scores and higher activations in ACC relative to real motion, but no differences in shape-selective areas emerged. This pattern of brain activation is consistent with the attentional gradient model or bottom-up accounts of ILM in preference to impletion.”
“To our

knowledge, there are limited small case series reports on endoscopic component separation (ECS) and no single institutional study comparing the difference in outcomes between laparoscopic and open ventral hernia repairs following endoscopic component separation. A single institutional retrospective review was performed, identifying this website 42 patients who underwent endoscopic component separation at a single institution by a single surgeon for ventral hernia repair with prosthesis from 2010 to 2013. Seventeen patients underwent subsequent open ventral hernia repair (OHR) and 25 underwent SBI-0206965 supplier laparoscopic ventral hernia repair (LHR). Demographics, surgical factors, wound complications and hernia occurrence post-operatively were reviewed. Surgical factors/demographics were similar between groups. All patients achieved primary fascial and skin closure. Operative time for the laparoscopic group was significantly shorter than the open group (278 vs. 378 min; P = 0.0001), and there was a trend towards a shorter hospital stay in the

laparoscopic group (laparoscopic, 4 days; open, 5 days; P = 0.063). Estimated blood loss per case with ECS and subsequent laparoscopy was significantly lower than in the open cases (63 vs. 147 cc; P = 0.0017). In both groups, wound complications occurred in five patients (laparoscopic, 20 %; open, 29 %; P = 0.71). There was one midline hernia recurrence and two lateral abdominal wall hernia occurrences post-operatively in the laparoscopic group, whereas there were no midline and one lateral wall hernia occurrence in the open group. Patients undergoing endoscopic component separation with subsequent laparoscopic fascial reapproximation had a significantly shorter operative time and estimated blood loss when compared with open fascial reapproximation. Wound complications were similar in both groups although there were a greater number of hernia occurrences post-operatively in the laparoscopic group, though of no statistical significance.

032) and significantly lower concentrations of cysteinylglycine (

032) and significantly lower concentrations of cysteinylglycine (p = 0.009) and taurine (p = 0.0002) than controls. Conversely, there were no significant differences in plasma homocysteine, glutamylcysteine, and glutathione between CRVO patients and controls. When categorized by CRVO type (ischemic/non-ischemic), taurine was still lower in both subgroups than in controls, whereas cysteine, cysteinylglycine, as well as homocysteine, were significantly higher only in the ischemic subgroup. In non-ischemic CRVO, cysteinylglycine fell

just short of statistical significance (p = 0.06). Logistic regression analysis revealed an odds ratio of 1.02 (95% confidence interval Selleckchem ACY-241 (CI): 1.01-1.04, p = 0.001) for cysteine, 0.79 (95% CI: 0.70-0.89, p = 0.0002) for cysteinylglycine, and 0.94 (95% CI: 0.90-0.97, p = 0.002) for taurine.\n\nConclusions: Results suggest that reduced plasma levels of cysteinylglycine and taurine may contribute to the pathogenesis of both CRVO types. Furthermore, this study also demonstrated an association between ischemic CRVO and higher concentrations of homocysteine and cysteine.”
“The current epidemic of hospital- and community-acquired

methicillin-resistant Staphylococcus aureus (MRSA) infections has caused significant human morbidity, but a protective Selleck PFTα vaccine is not yet available. Prior infection with S. aureus is not associated with protective immunity. This phenomenon involves staphylococcal protein A (SpA), an S. aureus surface molecule that binds to Fc gamma of immunoglobulin (Ig) and to the Fab portion of V(H)3-type B cell receptors, thereby interfering with opsonophagocytic clearance of the pathogen and ablating adaptive immune responses. We show that mutation of each of the five Ig-binding domains of SpA

with amino acid substitutions abolished the ability of the resulting variant SpA(KKAA) to bind Fc gamma or Fab V(H)3 and promote B cell apoptosis. Immunization of mice with SpA(KKAA) raised antibodies that blocked the virulence of staphylococci, promoted opsonophagocytic clearance, and protected mice against challenge with highly virulent MRSA Napabucasin chemical structure strains. Furthermore, SpA(KKAA) immunization enabled MRSA-challenged mice to mount antibody responses to many different staphylococcal antigens.”
“P>Brain-derived neurotrophic factor and neurotrophin-4 high-affinity receptor tropomyosine related kinase (Trk) B is required for the differentiation and maintenance of specific neuron populations. Misregulation of TrkB has been reported in many human diseases, including cancer, obesity and neurological and psychiatric disorders. Alternative splicing that generates receptor isoforms with different functional properties also regulates TrkB function.

We determined levels of CD3 and selected

We determined levels of CD3 and selected Adavosertib chemokine and cytokine gene expression by quantitative real-time PCR.\n\nResults: IRF7 gene expression increased in the CNS as disease progressed. IRF7 message was localized to microglia and infiltrating leukocytes. Furthermore, IRF7-deficient mice developed more severe disease. Flow cytometric analysis showed that the extent of leukocyte infiltration

into the CNS was higher in IRF7-deficient mice with significantly higher number of infiltrating macrophages and T cells, and the distribution of infiltrates within the spinal cord was altered. Analysis of cytokine and chemokine gene expression by quantitative real-time PCR showed significantly greater increases in CCL2, CXCL10, IL-1 beta and IL17 gene expression in IRF7-deficient mice compared with WT mice.\n\nConclusion: Together, our findings suggest that IRF7 signaling Selleckchem Combretastatin A4 is critical for regulation of inflammatory responses in the CNS.”
“Engelmann J, Gertz S, Goulet J, Schuh A, von der Emde G. Coding of stimuli by ampullary afferents in Gnathonemus petersii. J Neurophysiol 104: 1955-1968, 2010. First published August 4, 2010; doi:10.1152/jn.00503.2009. Weakly electric fish use electroreception for both active

and passive electrolocation and for electrocommunication. While both active and passive electrolocation systems are prominent in weakly electric Mormyriform fishes, knowledge of their passive electrolocation ability is still scarce. To better estimate the contribution of passive electric sensing to the orientation toward electric stimuli in weakly electric Selleckchem HSP990 fishes, we investigated frequency tuning applying classical input-output characterization and stimulus reconstruction methods to reveal the encoding capabilities of ampullary receptor afferents. Ampullary receptor afferents were most sensitive (threshold: 40 mu V/cm) at low frequencies (< 10 Hz) and appear to be tuned to a mix of amplitude and slope of the input signals. The low-frequency tuning was corroborated by behavioral experiments, but behavioral thresholds were one order of magnitude higher. The integration

of simultaneously recorded afferents of similar frequency-tuning resulted in strongly enhanced signal-to-noise ratios and increased mutual information rates but did not increase the range of frequencies detectable by the system. Theoretically the neuronal integration of input from receptors experiencing opposite polarities of a stimulus (left and right side of the fish) was shown to enhance encoding of such stimuli, including an increase of bandwidth. Covariance and coherence analysis showed that spiking of ampullary afferents is sufficiently explained by the spike-triggered average, i.e., receptors respond to a single linear feature of the stimulus. Our data support the notion of a division of labor of the active and passive electrosensory systems in weakly electric fishes based on frequency tuning.

05, 95% confidence interval (CI) 0 86 to 1 27, six trials, 3694 i

05, 95% confidence interval (CI) 0.86 to 1.27, six trials, 3694 infants), neonatal respiratory distress syndrome (average RR 1.05, 95% CI 0.91 to 1.22, nine trials, 3833 infants), or chronic lung disease (RR 1.01, 95% CI 0.85 to 1.19, five trials, 2511 infants), and did not improve any of the secondary fetal, neonatal or childhood outcomes assessed by intention-to-treat analyses.\n\nIndeed, the data showed prenatal TRH to have adverse effects for women and their infants. All side effects reported (nausea, vomiting, light headedness, urgency of micturition,

facial flushing) were significantly more likely to occur in women receiving TRH. In the infants, prenatal JNK-IN-8 inhibitor TRH increased the risk of needing respiratory support (RR 1.16, 95% CI 1.03 to 1.29, three trials, 1969 infants), and of having a low Apgar score at five minutes (RR 1.48, 95% CI 1.14 to 1.92, three trials, 1969 infants). Only three trials provided data on childhood follow-up, and while one trial suggested poorer outcomes

for infants who were exposed to prenatal TRH, the other two buy 3-MA trials, that assessed infants using an established developmental instrument, showed no clear differences between groups in follow-up outcomes.\n\nSensitivity analyses by trial quality, or subgroups with differing times from entry to birth, or different dose regimens of TRH, did not change these findings.\n\nAuthors’ conclusions\n\nPrenatal buy BMS-754807 TRH in addition to corticosteroids, given to women at risk of preterm birth, does not improve infant outcomes and can cause maternal side effects.”
“Successful natural orifice transluminal endoscopic surgery (NOTES) procedures have been reported in animal studies. However, very little is known about the optimal approach for the application of these surgeries in the thoracic cavity. This study presents the feasibility of transtracheal evaluation

of pleural cavity in a canine model using the NOTES technique. (C) 2009 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved.”
“Schiff bases and their metal complexes have antiviral, antimicrobial, antitumoral, radical scavenging and antioxidant activities. In this study, effects of Schiff base ligand and its metal complexes on the fatty acids and lyphophlilic vitamins of the liver of rats were investigated. The fatty acids of the liver were determined by GC and lyphophlilic vitamins of the liver determined by HPLC. The amounts of stearic acid (18:0), oleic acid (18:1) and monounsaturated fatty acids (MUFA) considerably decreased in the Mn, Ni and Zn complexes groups, whereas the amount of linolenic acid (18:3) and eicosatrienoic acid (20:3) considerably increased in the Ni an Zn complexes groups compared to the control group (P<0.01). However, there was no significant difference (P>0.


“Electrochemical-catalytic conversion via the electrochemi


“Electrochemical-catalytic conversion via the electrochemical-catalytic cell (ECC) is effective at 400 degrees C for simultaneous NOx and hydrocarbons emissions control of lean-burn gasoline engine without consuming any reductant. The NO reaction is direct NO decomposition. The NOx to N-2 rate over the cathode of the ECC can be three orders larger than those

over conventional oxide catalysts for NO decomposition. In the high NOx concentration region, the NO conversion increases with increasing NOx concentration; https://www.selleckchem.com/products/p5091-p005091.html this characteristic allows the engine to be operated at high enough temperature with excess oxygen to result in maximum fuel efficiency. In the low NOx concentration region, the NO conversion selleck chemicals also increases with decreasing

NOx concentration; this characteristic enables complete conversion of NO and thus can result in zero NOx emission. The NO conversion increases with decreasing temperature, at least till 400 degrees C. Higher oxygen concentration is beneficial to both the NO conversion and the hydrocarbons oxidation to result in zero pollution. (C) 2011 Elsevier B.V. All rights reserved.”
“Choice reaction times are shorter when stimulus and response locations are compatible than when they are incompatible as in the Simon effect. Recent studies revealed that Simon effects are strongly attenuated when there is temporal overlap with a different high-priority task, accompanied by a decrease of early location-related response priming as reflected in the lateralized readiness potential (LRP). The latter result was obtained in a study excluding overlap of stimulus location with any other dimension in the tasks. Independent evidence suggests that location-related priming might be present in conditions with dimensional overlap. Here we tested this prediction in a dual-task experiment supplemented with recording LRPs. The

secondary task was either a standard Simon task where irrelevant stimulus location selleck inhibitor overlapped with dimensions of the primary task or a Stroop-like Simon task including additional overlap of irrelevant and relevant stimulus attributes. At high temporal overlap, there was no Simon effect nor was there stimulus-related response priming in either condition. Therefore stimulus-triggered response priming seems to be abolished in conditions of limited capacity even if the likelihood of an S-R compatibility effect is maximized.”
“Tamoxifen-resistant breast cancer is a major clinical problem and new treatment strategies are highly warranted. In this study, the multitargeting kinase inhibitors sorafenib and nilotinib were investigated as potential new treatment options for tamoxifen-resistant breast cancer. The two compounds inhibited cell growth, reduced expression of total estrogen receptor alpha (ER), Ser118-phosphorylated ER, FOXA1 and AIB1 and resensitized tamoxifen-resistant cells to tamoxifen.

The proliferation rate of AMSCs was faster than of BMSCs (doublin

The proliferation rate of AMSCs was faster than of BMSCs (doubling time 28h vs. 39h) and the capacity to suppress T cell proliferation and activation was weakened in AMSCs. In addition, both sources of cells were able to differentiate into bone, fat, and cartilage which proved their stem cell properties.\n\nConclusions: Cell origin and abundance were decisive factors in stem cell applications and with

the same premise as for AMSCs and BMSCs, adipose tissue is a more promising source of stem cells. (Clin. Lab. 2012;58:897-903. DOI: 10.7754/Clin.Lab.2012.120312)”
“P>This study was aimed to demonstrate the morphological and histochemical properties of the Harderian gland in the Angora rabbit. Ten healthy adult Angora rabbits obtained from private breeders Small molecule library concentration constituted the material of the study. The Harderian gland, which is composed of the pink and white lobes, consists of cells that produce a secretion of lipid character. The pink lobe contained type I cells with large lipid vacuoles. Cells with small lipid vacuoles (type II) were found in the white lobe. Type III cells containing both large and small lipid vacuoles were not observed. While type I cells reacted strongly

to staining with Oil red O, type II cells reacted weakly to this www.selleckchem.com/products/lazertinib-yh25448-gns-1480.html stain. The number of plasma cells was greater in the white lobe when compared to the pink lobe. The apical granules within the epithelial cells lining the intralobular and inter-lobular excretory ducts of the gland

were positive for periodic acid-Schiff (PAS), periodic acid-Schiff/alcian blue (PAS/AB), alcian blue (AB) and performic acid/alcian blue (PA/AB). Electron microscopic examination revealed that type I cells contain large PF-04929113 datasheet electron-light lipid vacuoles and an eccentric heterochromatic nucleus, due to the presence of these vacuoles. The cells, which were connected by tight junctions, possessed apically located microfolds. The nucleus of type II cells was situated basally and had an oval shape. Type II cells had apical microvilli-like cytoplasmic protrusions, longer than those of type I cells. Oval shaped myoepithelial cells were observed between the glandular epithelial cells and their basal lamina. The epithelium lining the excretory ducts of the gland contained two types of granules, which were dark and lightly coloured. Histochemical and ultrastructural examinations revealed no difference in the structure of the Harderian gland between female and male Angora rabbits.”
“Objectives: The present single centre study aims at analyzing the impact on renal allograft outcome of the important changes which occurred in the transplant population and immunosuppressive therapy during the last two decades.