Starks and colleagues  reported a lowered stress response to moderate intensity cycling exercise (65% – 85% VO2max) following 10 days of supplemention with 600 mg of phosphatidylserine, reflected by a reduced cortisol response to exercise. However, Kingsley and colleagues  were unable PI3K inhibitor to support an improved recovery in individuals performing an acute bout of eccentric exercise (downhill running). Investigations examining the combination of these phospholipids on enhancing exercise performance are limited, especially in exercise involving power performance and reaction time. Thus, the purpose of this study was to examine the acute effect of a low-dose
combination of these phospholipids on reaction time, anaerobic power and subjective measures www.selleckchem.com/products/loxo-101.html of alertness, energy, fatigue, and focus in health college students. Methods Subjects Nineteen subjects (17 men and 2 women) volunteered for this study. Following an explanation of all procedures, risks, and benefits, each subject gave their informed consent to participate in this study. The Institutional Review Board of the College approved the research protocol. Subjects were not permitted to use any MLN2238 concentration additional nutritional supplements throughout the experimental period. Screening for supplement use
was accomplished via a health history questionnaire completed by the subjects others during recruitment. All subjects were
recreationally active for at least three months prior to the investigation. Subjects were randomly assigned to a group that either consumed the supplement (21.1 ± 0.6 years; height: 180.2 ± 6.1 cm; body mass: 80.6 ± 9.4 kg; body fat %: 11.3 ± 6.9%) or a placebo (21.3 ± 0.8 years; height: 181.3 ± 10.2 cm; body mass: 83.4 ± 18.5 kg; body fat %: 14.9 ± 7.7%). The study was conducted in a double-blind format. Study Protocol Subjects reported to the Human Performance Laboratory on two separate occasions (T1 and T2) for testing. Each testing session was separated by 4-weeks. Subjects were instructed to refrain from consuming any caffeine products on the day of each testing session and from performing any strenuous physical activity for the previous 12 hours. In addition, subjects were instructed not to eat or drink for 3 hours prior to each trial. Following a 10-min resting period subjects were provided with either the supplement (CRAM) or the placebo (PL). Subjects then rested quietly for 10-minutes prior to completing a 9-question survey ascertaining their subjective feelings for that moment relating to alertness, energy, fatigue, focus, and well-being. Following the survey subjects performed a 4-min reaction test (PRE). Upon completion of the reaction test subjects performed an additional 10-min of exhaustive exercise before repeating the survey and reaction test (POST).