(B) The superimposed RSS waveforms from all subjects at the sensor
showing the largest activation following passive movement. … Source locations and time courses of source activities (BESA analysis) Figure 4 shows the isocontour maps over the left hemisphere at 34 msec, 89 msec, 121 msec, and over the right hemisphere at 140 msec after active and passive movements in a representative subject. The field distribution displayed a distinctly different pattern under the active and passive movements. Source activities >80 msec were observed only after the PM. Figure 4 Isocontour maps over the left hemisphere at 34 msec, 89 msec, 121 msec, and over the right Inhibitors,research,lifescience,medical hemisphere at 140 msec after active (A) and passive (B) movement in a representative subject. Inhibitors,research,lifescience,medical The peak of MEF1 and PM1 after active and passive movements was observed … ECD of MEF1 was located at the sensorimotor area over the hemisphere contralateral to the movement in all subjects. Secondary ECDs after active movement were estimated to be in various areas; for example, at SMA, premotor area, PPC, contralateral secondary somatosensory cortex (cS2), iS2, ipsilateral primary sensory area, and some other areas below the corpus callosum. However, GOF was not >80% after four Inhibitors,research,lifescience,medical or five ECDs were estimated, and we could not find a consistent
tendency in ECD locations after the first source was estimated following active movement, despite using the multiple source analysis method. In contrast, Inhibitors,research,lifescience,medical we found several ECD locations around
the sensory and motor cortices following PM. The first source for the peak of PM1 was estimated to be in the primary sensorimotor area, at almost the same location as that of MEF1 in all subjects. After the first source was estimated, the second, third, fourth, and fifth ECDs were estimated to be at SMA in 12 subjects, PPC in seven subjects, cS2 in seven subjects, and iS2 in seven subjects. Figure 5 presented ECDs following PM MEK inhibitor overlapping on the subject’s inflated brain at a representative subject. ECDs were estimated at primary sensorimotor area, SMA, PPC, and cS2 in this subject. Figure 5 ECDs following passive movement overlapping on the inflated brain of a representative Inhibitors,research,lifescience,medical subject. ECDs were estimated at the primary sensorimotor area (red dipole), SMA (green dipole), PPC (purple dipole), and cS2 (blue dipole) in this subject. ECDs, equivalent … The peak latency and moment of each source activity are presented in Table below 2. Figure 6 shows the time course of each source activity for all subjects and the average for each source activity following active and passive movements. The peak of the source activities in area 4 was 30.2 ± 10.7 nAm and was observed 33.5 ± 6.3 msec after active movement. The peaks of each source activity were observed 36.0 ± 11.6 msec in area 4, 74.5 ± 16.0 msec in SMA, 89.7 ± 19.7 msec in PPC, 129.4 ± 20.4 msec in cS2, and 128.0 ± 38.4 msec in iS2. The peak activities were 29.2 ± 12.2 nAm in area 4, 14.8 ± 5.1 nAm in SMA, 17.8 ± 5.