The Selleck ATM/ATR inhibitor qualitative studies also lacked depth in the data that were collected, represented,

and interpreted, leaving further interpretation and synthesis of the findings difficult. Despite this, the main outcome of agitation was measured by the CMAI in all studies reporting on that outcome, and this tool is known to be a valid and reliable measure.38 Dementia research, in general, may benefit from an agreed set of tools to measure common mood and behavior-related outcomes and agreed ways in which to measure more physical/physiological outcomes, such as sleep, physical activity, and falls. Future research also may need to consider what outcomes are the most relevant to measure and how they should be measured and interpreted across studies. In particular, in the evidence synthesized here there was a lack of quality-of-life outcomes and a lack of consistency in the recording of medication use and occurrence of falls. The measurement of quality-of-life issues in people with dementia is a complex issue, but recently a measure based on the standardized European Quality Of Life (EUROQOL) tool39

NVP-BGJ398 chemical structure has been designed specifically for measuring Dementia-related Quality Of Life (DEMQOL),40 which may assist future research in this area. From the evidence collected in this review, it is not clear how much of an impact the different residential environments may have had on the outcomes. However, what is clear is the concern and interest around this area, and the necessity for higher-quality research to understand the mechanisms behind interventions and evaluate them.10 and 11

There may be important features about the interactions between staff and residents, and the residents themselves, as well as with the physical environment in specialized dementia units in comparison with homes with a mix of elderly people with and without dementia. Equally, the features of the garden (eg, a general yard versus a landscaped garden versus a dementia-specific garden) also may have an impact on the level of benefit residents with dementia may gain. There is a glut of literature that has looked at the design of gardens specialized for the elderly and for Olopatadine those with dementia41 but the recommendations appear as yet to be unused in the research literature. All these aspects will be important to consider in future research for them to be explored in future syntheses. The measurement of medication usage or prescribing often was not recorded in these studies, but consistent reporting of this across studies would help us to understand if the effectiveness of the garden in residents’ mood and behavior is also reflected in the use of medications for those residents.

In addition, Corner et al. (22) reported on a Phase II trial from the United Kingdom that includes 110 men with locally advanced

disease treated with HDR monotherapy to doses of 34 Gy in four fractions, 36 Gy in four fractions, or 31.5 Gy in three fractions. The rate of acute urinary retention requiring catheterization was 6.4%, and there see more were no PSA relapses with a median followup of 30 months (34 Gy), 18 months (36 Gy), and 11.8 months (31.5 Gy). Also, Yoshioka et al. (23) has reported on a Japanese series of 112 men treated with hormonal therapy and HDR monotherapy to 54 Gy in nine fractions over 5 days in which the 5-year PSA failure-free survival was 83%despite more than one-half of the patients having high-risk disease. Finally, Mark et al. (24) of Lubbock, Texas have presented

in abstract form on their large series of 312 HDR monotherapy patients treated to 4500 cGy in six fractions to the prostate and seminal vesicles given as two implants of three fractions each, spaced 4 weeks apart. None of the patients received ADT, and with a median followup of 8.2 years, the PSA failure-free survival was 84.6%. In the setting of prior pelvic radiation, UCSF investigators have published two series using a regimen of 36 Gy in six fractions given as three fractions per implants, with the implants being spaced 1 week apart. The first series by Lee et al. (1) in 2007 detailed 21 patients who had received prior external beam radiation (19) or LDR brachytherapy (2) for prostate cancer and developed a biopsy-proven local recurrence at an average of 5.25 years after initial radiation. ABT-263 Nine of the patients had extracapsular extension or seminal vesicle invasion. Eleven received neoadjuvant ADT before salvage HDR. The 2-year PSA failure-free survival was 89% and the maximum gastrointestinal toxicity was only Grade 2, but the median followup was only 18.7 months.

The second series by Jabbari et al. (2) was of 6 patients who developed prostate cancer after receiving a prior abdominopelvic resection. All had received prior pelvic radiotherapy to a median dose of 45 Gy (range, 21–73.8 Gy). however With a median followup of 26 months (range, 14–60months), no patient had experienced a biochemical recurrence, and none had higher than a Grade 3 acute toxicity, although 1 patient developed a urethral stricture that required dilation. Rectal fistula is a very rare complication of primary brachytherapy in patients who have not received prior radiation (25). However, it has been reported in 3.4% of the 251 cases of salvage brachytherapy reported in the literature from 1990 to 2007. The Dana–Farber Phase I/II study identified an interval to reirradiation of less than 4.5 years as a risk factor for developing a fistula, which placed our patient at higher risk because his interval to reirradiation was only 2.5 years. However, no dosimetric risk factors for fistula have been identified in this setting, and therefore the goal was to keep the rectal dose as low as possible.

, 1999). Our findings showing bioenergetics impairment and oxidative stress caused by the major compounds accumulating in HHH syndrome may be interrelated since mitochondrial dysfunction is often associated with large increase of reactive species generation because oxidative phosphorylation is the major source of free radicals, which Everolimus concentration are byproducts of the cell respiratory cycle (Lemasters et al., 1999). Furthermore, low energy and oxidative

damage are key events facilitating the pathogenic cascade leading to necrotic or apoptotic cell death especially in neurons, whose viability highly depends on large amounts of energy to preserve the resting membrane potential (Kroemer and Reed, DAPT molecular weight 2000 and Martin et al., 1994). We cannot also exclude the possibility that creatine deficiency, that occurs

in OAT deficiency, may also play a role in the neuropathology of HHH syndrome, but this should be further investigated (Dionisi Vici et al., 1987 and Valayannopoulos et al., 2009). In summary, the current findings provide insight into possible mechanisms of brain damage in HHH syndrome caused in vivo by Hcit and Orn and indicate that the pathogenesis of this disorder cannot be exclusively attributed to hyperammonemia. Furthermore, the bioenergetics dysfunction caused by Hcit and Orn may explain the mitochondrial abnormalities and the increased urinary excretion of lactate, 2-hydroxyglutyrate, various CAC intermediates and glutaric acid that may be observed in patients with HHH syndrome. Therefore, it is conceivable that, besides a diet poor in proteins that is chronically used, prompt and aggressive treatment of infections with high caloric intake (to reduce the risk of increased catabolism

with elevation of brain Orn and Hcit concentrations) and possibly with antioxidants seems justified to avoid aggravation of the brain injury in these patients, especially during acute metabolic decompensation. All chemicals were purchased from Sigma Chemical Co., St. Louis, MO, USA, except for [U-14C] glucose and [1-14C] acetate, which learn more were purchased from Amersham International plc, UK and homocitrulline, which was obtained from MP Biomedicals, LLC Solon, Ohio, USA. Ornithine, homocitrulline, N-acetylcysteine, ascorbic acid (vitamin C) and α-tocopherol (vitamin E) were dissolved in saline solution (NaCl 0.9%). Thirty-day-old Wistar rats obtained from the Central Animal House of the Departamento de Bioquímica, ICBS, UFRGS, were used in the assays. The animals had free access to water and to a standard commercial chow and were maintained on a 12:12-h light/dark cycle in an air-conditioned constant temperature (22 ± 1 °C) colony room. The “Principles of Laboratory Animal Care” (NIH publication no.

However, in relation to solid food, which provided the nutritional intake of Ca and P, nutritional pairing was achieved. Even though controlling

the amount of alcohol consumed by the animals was achieved, another limitation of our experiment was the absence of evaluating blood alcohol concentrations. Other studies could include the measurement of this in their experimental designs. Finally, it is important to consider that our work was limited to Ca/P ratio analysis. Without other parameters of evaluation, it was only possible to correlate the results with other searches. Broader studies are therefore required to better verify the potential relevance of these results in dental practice. It can be concluded that ovariectomy associated with alcohol consumption of 20% led to a significant decrease in Ca/P ratios within the region of alveolar bone crest in rats. Pictilisib E7080 nmr The authors

acknowledge support from CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brazilian Federal Agency for Support and Evaluation of Postgraduate Education), native English speaker V. Hegenberg and statistician consultant, J. Adans. Funding: Adriana M.P.S. Marchini received a scholarship from the Brazilian governmental research agency, CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior). Competing interests: The authors report no conflict of interest relating to this study. Ethical approval: This study was approved by the ethics committee of São José dos Campos School of Dentistry, Meloxicam State University

of São Paulo – UNESP (Protocol No. 021/2008-PA/CEP). “
“Forensic identification of victims is essential for humanitarian reasons, but also for civil or criminal investigations. Identification of a corpse is essentially based on anthropology, odontology, fingerprints, radiology, and/or DNA typing.1 However, it can be complicated when the corpse is old, completely destroyed from mass disaster or putrefactive, skeletonized, drowned, or burned. In these cases, identification is usually difficult1, 2 and 3 since the elements used by pathologists, anthropologists and/or odontologists (such as fingerprints, sexual characteristics, physical constitution, ethnic group, stature and/or dental arch) can be modified by degradation, hampering a conclusive result. Given this scenario, forensic specialists looking for better preserved tissues to obtain DNA with good quality and amount4 and 5 have turned to DNA analysis.6, 7, 8 and 9 An excellent alternative is the use of cells from inside molar and pre-molar teeth. Regarding the molar and pre-molar mineralized inert structure, size, and location,4, 10, 11, 12, 13 and 14 they preserve cells with high molecular weight DNA for longer periods even when the body is in an advanced state of decomposition.

0%, p = 0.02), the incidence of a high-grade restenosis ≥70% showed no significant find more difference between the two groups (3.3% vs. 2.8%). A clinical impact of an ISR on ipsilateral stroke or death during follow-up could not be observed. Advanced age was a clinical risk factor, which could be identified to be predictive for developing carotid restenosis [17]. To date, to the best of our knowledge, no data about rates of restenosis have yet been published by the other commonly known large randomized controlled studies

comparing CEA and CAS especially the International Carotid Stenting Study (ICSS) [31], the Carotid Revascularization Endarterectomy vs. Stenting Trial (CREST) [4], and the Stenting and Angioplasty with Protection in Patients at High Risk for Endarterectomy study (SAPPHIRE) [11] and [32]. Within the analysed non-randomised trials, there was a wide range concerning the amount of treated patients. The smallest study included 100 patients [33]; the largest number of CAS patients was enrolled in the study of Setacci et al. (n = 814) [25]. In the vast majority, patients aged 60 years or over with roughly two-thirds male sex were included in the reviewed studies. The relevant data which were extracted are delineated in Table 1. The diagnostic tool used to detect an ISR was serial duplex ultrasound in all studies (n = 13).

A confirmatory diagnostic procedure such BIBW2992 nmr as CTA or conventional angiography had been carried out after ultrasound in ten studies [19], [21], [22], [23], [24], [25], [26], [27], [29] and [30]. Notably, there was a wide variation concerning the ultrasound criteria applied for the detection of an ISR between the studies. As one of the main key features for the detection of a restenosis, a cut-off peak systolic

velocity is mentioned [19], [22], [24], [26], [28], [29] and [30] sometimes in addition to other criteria such as end-diastolic velocity or the ICA/CCA index [18], [20], [21], [23], [25] and [27]. Although the minority of the studies reported concise details about the exact time point of ISR occurrence, most ISR were found Ergoloid to occur within the first year (median: 8 months, IQR: 7–9) after CAS [16], [18], [20], [21], [26], [29] and [30]. There was a broad range concerning the clinical complications for patients with ISR between 0% [21], [22], [24], [26] and [29] and 25% [30] for stroke and from 0% [19], [21], [22], [23], [25], [26] and [29] to 11.1% [18] for death, respectively. Common baseline characteristics like advanced age [19], female gender [19], prior revascularization treatment, [23], [25], [27], [34] and [35] the treatment of a radiogenic stenosis [23] or prior neck cancer [21] could be found to be predictive for ISR development. Furthermore, some cardiovascular risk factors such as smoking [17], lowered HDL cholesterol, [26] diabetes mellitus [22] or elevated HbA1c [18] and [36] could be identified as predictors for ISR, too.

“
“Sickle cell disease (SCD), is a hematologic disorder caused by an autosomic recessive inherited mutation in the hemoglobin genes (HbS), is considered the most frequent hemoglobinopathy in the world, with a peak incidence in the African population. SCD is see more reported as the first cause of stroke in childhood; children with homozygous HbS genes have a yearly first stroke risk of approximately 0.5% [1]. According to the STOP study (stroke prevention trial in sickle cell anemia) [2], the stroke risk in these patients could be predicted by

TAMM (time-averaged mean of maximum blood flow) velocities detected by transcranial Doppler sonography (TCD) in the major intracranial arteries. Patients are categorized as “normal” if TAMM is <170 cm/s, “conditional” if TAMM is between 170 and 200 cm/s, “abnormal” if TAMM is >200 cm/s. Children with “abnormal” values are at the highest risk of stroke and are advised to undergo blood transfusion, in order

to reduce that risk. However, there are many reports of SCD patients with “normal” TAMM velocities harboring silent strokes at MRI; the prevalence of these lesions is higher than in the normal population [3] and [4]. For this reason, we conducted a study to investigate whether the detection of a significant side-to-side asymmetry in patients with normal TAMM values could identify those subjects, which are more prone to develop silent strokes. We enrolled in this study thirty-one SCD patients (15 females; Selleckchem Ku0059436 mean age: 9.23 ± 3.66 years; age range: 4–14 years), previously categorized as “normal” according to the STOP protocol, which never received blood transfusions, and did not have a clinical history of TIA/stroke. A complete TCD examination was performed by an experienced neurosonographer, in a quiet atmosphere and without pharmacological sedation, using a 2 MHz pulsed-wave Doppler probe Methocarbamol (Viasys Healthcare, Model Sonara) to

explore the major intracranial arteries through the temporal bone-window: TAMM velocity was recorded bilaterally in the middle cerebral artery, anterior cerebral artery and posterior cerebral artery and stored on a database. Offline side-to-side comparison of TAMM values allowed detecting a significant asymmetry, as defined by Zanette et al. [5]. All patients also underwent brain magnetic resonance imaging (MRI) by means of a 1.5 T MR scanner (Achieva, Philips, Best, the Netherlands). The study protocol included axial fluid attenuated inversion recovery (FLAIR) sequence (repetition time 11,000 ms; echo time 140 ms; inversion time: 2800; echo train length 53; flip angle 90°; field of view 230 mm; matrix 256 × 256; slice thickness 5 mm; interslice gap 0.5 mm; number of averages 2) to disclose ischemic lesions. Lesion area was manually traced on all images by a neuroradiogist with experience in pediatric neuroradiology on a dedicated console and software (Medstation).

Binding to 5′-GMP in the cell-free setting suggests the possibility of DNA interactions, at least for the ruthenium complexes, but cannot explain the cytotoxic potency of the osmium analogues. Moreover, other ruthenium complexes such as KP1019 are known to avidly bind proteins, both extra- and

intracellular [20], lowering the probability that DNA interaction is relevant for their antitumor activity in vivo. Cell biological activities of ruthenium/osmium complexes with modified http://www.selleckchem.com/products/EX-527.html paullone (indolobenzazepine) ligands derived from known Cdk inhibitors were characterized in human cancer cell lines in vitro. Apart from the beneficial effect on aqueous solubility, the presence of the paullone ligands

seems to be favorable for biological activity as well. All of these compounds inhibit cancer cell growth in low micromolar concentrations and induce apoptotic cell death (to a lower extent also necrosis). The capacity of Cdk inhibition could be demonstrated in the cell-free setting, but is rather unlikely to be decisive for the antiproliferative mTOR inhibitor activity of the complexes studied here, given the weak effects on cell cycle progression. Further investigations will be required to clarify the actual basis for their mechanism of action. BrdU Bromodeoxyuridine We are indebted to the Austrian Science Fund (FWF) for financial support (project no. P20897-N19). G. Schmetterer (Institute of Physical Chemistry, University of Vienna) is gratefully acknowledged for providing the radiochemical facilities for kinase experiments. V. Dirsch and D. Schachner (Department of Pharmacognosy, University of Vienna) are gratefully

acknowledged for providing the FACS instrument and for the technical instructions, respectively. “
“The authors regret the change of authorship. The new list of authors and affiliations are shown above. The authors would like to apologize for any inconvenience caused. “
“Figure options Download full-size image Download as PowerPoint slide James Fee passed away last April 17 in San Diego at the age of 72 after a battle with prostate cancer. Jim’s scientific work on superoxide dismutases and the Tangeritin respiratory oxidases from thermophilic bacteria constitutes seminal contributions that have provided important insights into the structure and function of these enzymes. Jim was best known for his pioneering work in bioenergetics, an area that was the focus of his research interests during most of his career. We feel privileged to have known him. Jim’s scientific education began in 1961 with a double major in Chemistry and History at Pasadena College in California, followed by a Ph.D. in Biochemistry at the University of Southern California in 1967.

The functional images were registered to the 3D MP-RAGE volume and warped to the Montreal Neurological Institute (MNI)-152 standard template using FLIRT (Jenkinson, Bannister, Brady, & Smith, 2002). Statistical analyses were based on FILM, which performs pre-whitening, and fits a general linear model voxel-wise. Brain activity was modeled with

five predictors, (1) cue-primes, (2) neutral primes, (3) neutral trial targets, find more (4) valid trial targets and (5) invalid trial targets. The prime-predictors included both the display of the prime (50 ms) plus waiting time (450 ms) before target display. The target-predictors started at the target on-set time and ended when the subject responded. The expected signal time courses were convolved with a two-gamma hemodynamic response function (Glover,

1999) and its temporal derivative. Within-subjects parameter estimates were obtained separately for each run, and then pooled across runs with a fixed effects model of variance. SR, SR+/SP− and SR+/N− were entered buy Adriamycin as separate regressors in a mixed effects GLM analysis (FLAME; FMRIB’s Local Analysis of Mixed Effects) for the prime and target contrasts. In addition, a post hoc analysis was performed with the left and right RT priming effect as covariates in order to investigate the influence of a hand effect on brain activity. Z statistic images were thresholded using an uncorrected voxel p-value of .005 (Z = 2.576) and a cluster size threshold of ⩾20 voxels ( Lieberman & Cunningham, 2009). In the priming task, the reward can be seen as successful task compliance, defined by the researcher’s instructions as fast and accurate responses. Reward cues are primes and targets associated with successful task compliance. In order to isolate brain areas activated to unexpected reward cues, three statistical contrasts were examined; (1) prime (cue-primes > neutral primes) isolates activity related to unexpected reward-cues vs. unexpected non-reward cues; (2) neutral > valid (neutral trial targets > valid trial targets)

Isoconazole isolates activity related to unexpected reward-cues vs. expected reward-cues; (3) neutral > invalid (neutral trial targets > invalid trial targets) isolates activity related to unexpected reward-cues vs. unexpected non-reward-cues. To quantify the predictive value of SR, SP and N, the BAS related brain activity obtained in the voxel-by-voxel analysis was investigated in region-of-interests (ROI) analyses. The ROIs investigated were restricted to the left ventral striatum because activity here correlated with SR, SR+/SP− and SR+/N− in all three contrasts, and because the ventral striatum, was the location where BAS was expected to exert its largest influence. ROIs were based on activations in the three contrasts: ROI-1: prime, ROI-2: neutral > valid, ROI-3: neutral > invalid and defined separately by the SR+/SP− and SR+/N− related activation patterns, thus forming 6 ROIs.

I tu powstaje pytanie, kogo jest obowiązany poinformować lekarz, gdy chodzi o obowiązkowe i zalecane szczepienia ochronne

u dzieci. W przypadku osoby małoletniej lekarz powyższe informacje przekazuje osobie sprawującej nad nią pieczę lub opiekunowi faktycznemu (art. 17 ust. 9 ustawy). Dodatkowo w dokumentacji medycznej odnotowuje się fakt poinformowania osoby obowiązanej do oddania się obowiązkowemu szczepieniu ochronnemu lub osoby sprawującej nad nią prawną pieczę, albo opiekuna faktycznego, o obowiązku poddania się temu szczepieniu (§ 9 ust. 4 Rozporządzenia w sprawie Z-VAD-FMK solubility dmso obowiązkowych szczepień ochronnych). Dla dalszych naszych rozważań istotne jest wyjaśnienie pojęć „osoba sprawująca prawną pieczę” oraz „opiekun faktyczny”. Najczęściej osobami sprawującymi prawną pieczę nad osobą małoletnią będą rodzice. Jeżeli żadnemu z rodziców nie przysługuje władza rodzicielska albo są nieznani, to dla dziecka ustanawia się opiekuna prawnego. Jeżeli opiekun doznaje przemijającej przeszkody w sprawowaniu opieki nad małoletnim, sąd opiekuńczy ustanawia kuratora [6]. Istotne wątpliwości interpretacyjne Thiazovivin chemical structure budzi pojęcie opiekuna faktycznego. Definicję ustawową odnajdujemy w art. 3 ust. 1 pkt 1 Ustawy o prawach pacjenta i Rzeczniku Praw Pacjenta [1]. Jest to osoba sprawująca,

bez obowiązku ustawowego, stałą opiekę nad pacjentem, który ze względu na wiek, stan zdrowia albo stan psychiczny opieki takiej wymaga. W definicji tej akcentuje się dwa elementy, a mianowicie sprawowanie opieki bez obowiązku ustawowego (czyli old osoba sprawująca opiekę nie należy do kręgu przedstawicieli ustawowych, nie jest więc rodzicem ani innym prawnym opiekunem) oraz sprawowanie stałej opieki nad osobą jej wymagającą [7]. Okolicznością wymagającą stałej opieki nie jest doraźna sytuacja, lecz ustawowo wskazany:

wiek, stan zdrowia oraz stan psychiczny. O stałej pieczy można mówić wówczas, gdy sprawowana jest przez cały czas występowania okoliczności usprawiedliwiającej. O stałości pieczy nie decyduje długotrwałość jej sprawowania [8]. Może być zatem spełniony wymóg stałości pieczy, pomimo że nie wystąpi długotrwałość jej sprawowania. Czyli opiekunem faktycznym może być także ktoś, kto nie jest spokrewniony z pacjentem, jednak opiekuje się nim w sposób ciągły [9]. Aby opieka była stała, musi być całościowa i niepodzielna. Warunek ten nie jest więc spełniony, gdy osoba opiekuje się małoletnim periodycznie (np. w godzinach pracy rodziców w określonych dniach tygodnia), w pewnych okresach [10]. Czy zatem poinformowanie babci czy niani zgłaszającej się z dzieckiem np. na wizytę kontrolną spełni warunek poinformowania o szczepieniach ochronnych obowiązkowych i zalecanych? To zależy. Jeżeli np. dziecko przebywa pod opieką babci w związku z dłuższym wyjazdem rodziców za granicę, można mówić o stałości opieki i uznać babcię za opiekuna faktycznego.

The INICC network was established to address the urgent need of developing countries to significantly prevent, control and reduce DA-HAIs and their adverse consequences. We aim to encourage wider adherence to infection control programs in all INICC member hospitals, which will result in accompanying and significant DA-HAI reductions, particularly in the ICU setting. Similar to these hospitals in Egypt, any hospital worldwide is invited to join the INICC program, through

which infection control teams are furnished with training, tools and basic methods to conduct outcome and process surveillance. Moreover, through the publication of these confidentially collected data, the scientific evidence-based literature is advanced, which also contributes to effectively and systematically tackling this problem. The authors Afatinib chemical structure declare that they did not receive

any personal funding, and the funding for the activities carried out at INICC headquarters was provided by the corresponding author Victor D. Rosenthal and the Foundation to Fight against Nosocomial Infections. None declared. Every hospital’s Institutional Review Board agreed to the study protocol, and patient confidentiality was protected by codifying the recorded information, making it identifiable only to the ICT. Idea, conception and design: Victor D. Rosenthal; software development: Victor D. Rosenthal; assembly of learn more data: Victor D.

Rosenthal; analysis and interpretation of the data: Victor D. Rosenthal; epidemiological analysis: Victor D. Rosenthal; statistical analysis: Victor D. Rosenthal; administrative, technical, and logistic support: Victor D. Rosenthal; drafting of the article: Branched chain aminotransferase Victor D. Rosenthal; critical revision of the article for important intellectual content: all byline authors; final approval of the article: all byline authors; provision of study patients: all byline authors; collection of data: all byline authors; funding: Victor D. Rosenthal and the Foundation to Fight against Nosocomial Infections, which funds all of the activities at INICC headquarters. The authors thank the many health care professionals at each member hospital who assisted with the conduct of surveillance in their hospital, including the surveillance nurses, clinical microbiology laboratory personnel, and the physicians and nurses providing care for the patients during the study; without their cooperation and generous assistance, this INICC project would not be possible. The authors also thank Mariano Vilar, Debora Lopez Burgardt, Santiago Suárez, Denise Brito, Yuan Ding, Luciana Soken, Eugenia Manfredi, Darío Pizzuto, Julieta Sayar and Isaac Kelmeszes, who work at INICC headquarters in Buenos Aires, for their hard work and commitment to achieve INICC goals; the INICC country coordinators (Altaf Ahmed, Carlos A.